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Learn more about our antibody-drug conjugate linkers - high purity cathepsin cleavable linkers services and capabilities.
Shilpa can provide high pure Mc-Val-Cit-PABC-PNP linkers for various Antibody Drug Conjugation (ADC) programs. MC-Val-Cit-PAB-PNP, also known as Mc-Val-Cit-PABC-PNP, is a cathepsin cleavable ADC peptide linker.
Cathepsin B Specificity:
The Val-Cit will specifically be cleaved by cathepsin B. Because this enzyme is only present in the lysosome, the ADC payload will only be released in the cell. Shilpa also provides high quality payload required for ADC programs.
Mc-Val-Cit-PABC-PNP ADC Linker Structure and Mechanism
One of the most important characteristics of an efficient ADC linker is plasma stability following drug administration, which enables the ADC to localize to tumor cells. Premature payload release could harm healthy tissues and reduce the ADC's therapeutic index, but this stability keeps it from happening.
In order for the payload to attach to its target after internalization, the ADC should release it. For the ADC to remain homogeneous and stable in circulation, the antibody-linker conjugation method and the ADC linker's structure are essential.
Val-Cit peptide linkers specifically cleaved by cathepsin B in lysosomes for targeted payload release
Optimized linker design ensuring stability in circulation while enabling controlled release at target sites
Pharmaceutical-grade linker synthesis with stringent quality control for ADC program requirements
Complete ADC program support including both linkers and high-quality payloads for conjugation
