Shilpa Medicare Limited
Flow Chemistry Development

Flow Chemistry Development

Next-gen process intensification via continuous flow — safer, more efficient, scalable chemistry for APIs and intermediates.

Overview

Continuous flow chemistry enables reactions in a continuously flowing stream rather than traditional batch modes, offering superior process control, heat & mass transfer, safety, and scalability. Our platform spans from lab-scale development through validation and full manufacturing, aligning with cGMP standards and integrated into our CDMO services.

Next-gen process intensification via continuous flow

Safer, more efficient, scalable chemistry for APIs and intermediates

Continuous flow chemistry enables reactions in a continuously flowing stream rather than traditional batch modes, offering superior process control, heat & mass transfer, safety, and scalability. Our platform spans from lab-scale development through validation and full manufacturing, aligning with cGMP standards and integrated into our CDMO services.

Development

Overview / Purpose

In the development phase, we translate synthetic routes into flow-compatible processes. We explore reaction kinetics, residence time distributions, mixing strategies, inline analytics, modular reactor selection, and safety enablers. The goal: seamless transition from batch to continuous, with performance equaling or exceeding traditional methods.

Capabilities & Key Activities

  • Feasibility studies: adapting a traditional batch reaction to continuous flow
  • Screening of microreactor / tubular reactor / static mixer modules
  • Reaction optimization under flow: tuning concentration, temperature, flow rates, residence times
  • Inline analytical integration (e.g. IR, NIR, Raman, UV) for real-time monitoring
  • Modular setups to allow stepwise scale-up (lab → pilot)
  • Process safety assessments: thermal runaway studies, pressure control, containment of hazardous intermediates
  • Early impurity profiling under flow conditions

Development Benefits

Flow development allows rapid iteration, better control of reaction parameters, and early identification of scale-up challenges. It also enables safer handling of hazardous reagents or unstable intermediates, as they exist only for short residence times in small reactor volumes.