Route Scouting

Including for oncology

Overview

We provide end-to-end HPAPI services from early route identification through commercial-scale cGMP supply. Our facilities include multiple dedicated HPAPI suites (OEL / OEB compliance), isolator technology, enriched analytical lab support, and a robust payload/linker library. We support both oncology & non-oncology high potency compounds.

Purpose & What We Do

• •Identify synthetic routes (starting materials → intermediates → final HPAPI) that maximize yield, safety, cost-effectiveness, and minimize hazardous reagents
• •Evaluate multiple potential pathways including alternative reagents, greener chemistry, fewer steps, and minimal waste
• •Initial reaction screening: batch studies, microscopy, small-scale hazard assessment
• •Feasibility for scale-up in terms of reaction kinetics, mixing, heat load, exotherms

• •Collection of literature / patent review for route ideas
• •Lab-scale reaction trials in controlled environments (mg → g scale)
• •Hazard / safety review of reagents and reagents carry-over
• •Preliminary impurity profile estimation

• •Route comparison dossiers (pros/cons, yields, safety, cost)
• •Preliminary risk assessment (chemicals, thermal hazards)
• •Workflows for selected route(s) for further development